In vitro modulation of seizure-like activity with beta-cyclodextrin-complexed rufinamide

Abstract

The global health concern of pharmacoresistant epilepsy necessitates innovative therapeutic strategies. Drug resistance often arises due to complex pharmacokinetic challenges. Beta-cyclodextrin, known for enhancing drug solubility and stability, offers a potential solution for improving the efficacy of antiseizure medications. This study aims to investigate the impact of beta-cyclodextrin-complexed rufinamide on seizure-like activity using an in vitro model of temporal lobe epilepsy.

Keywords

• temporal lobe epilepsy
• beta-cyclodextrin
• rufinamide
• in vitro epilepsy model
• electrophysiology