Nature Communications (May 2021)
Club cell-specific role of programmed cell death 5 in pulmonary fibrosis
- Soo-Yeon Park,
- Jung Yeon Hong,
- Soo Yeon Lee,
- Seung-Hyun Lee,
- Mi Jeong Kim,
- Soo Yeon Kim,
- Kyung Won Kim,
- Hyo Sup Shim,
- Moo Suk Park,
- Chun Geun Lee,
- Jack A. Elias,
- Myung Hyun Sohn,
- Ho-Geun Yoon
Affiliations
- Soo-Yeon Park
- Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Jung Yeon Hong
- Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Soo Yeon Lee
- Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Seung-Hyun Lee
- Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Mi Jeong Kim
- Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Soo Yeon Kim
- Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Kyung Won Kim
- Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Hyo Sup Shim
- Department of Pathology, Yonsei University College of Medicine
- Moo Suk Park
- Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yonsei University College of Medicine
- Chun Geun Lee
- Molecular Microbiology and Immunology, Brown University
- Jack A. Elias
- Molecular Microbiology and Immunology, Brown University
- Myung Hyun Sohn
- Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- Ho-Geun Yoon
- Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23277-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Idiopathic pulmonary fibrosis (IPF) is a fatal adult lung disease. Here the authors investigate the functional significance of PDCD5 in club cells as a mediator of lung fibrosis and potential therapeutic target for IPF.
