Features of the etythropoesis upon treatment of chronic myeloid leukemia with tyrosine kinase inhibitor

Abstract

A functional activity of erythroid hematopoietic cells of patients with chronic myeloid leukemia, who were treated with tyrosine kinase inhibitor of the first and second generation was investigated. Samples of bone marrow of patients with resistance to tyrosine kinase inhibitor treatment show an increase of erythroid colonies number provided that there is erythropoietin in the culture medium. Furthermore, it was found that clone cells in culture in vitro acquire the ability to differentiate towards erythroid direction in the absence of a culture medium culturing exogenous erythropoietin when they have a resistance to imatinib and nilotinib. Thus, the determination of proliferative activity of erythroid hematopoiesis level in cultured cells in vitro may serve as an important prognostic factor for the further choice of treatment strategy.

Keywords

• chronic myeloid leukemia, tyrosine kinase inhibitors, erythropoiesis, cell culture in vitro