Comparative study of labetalol and nifedipine in management of hypertensive disorders of pregnancy in BRIMS tertiary care center

Abstract

Objective: To compare the efficacy and safety of oral labetalol and nifedipine in hypertensive disorder of pregnancy. Methods: A prospective comparative study was carried out in obstetrics and gynaecology department BRIMS tertiary care center between June 2019 to December 2019. This study included 60 antenatal women irrespective of parity and gestational age from 20-40 weeks with hypertensive disorder. Chronic hypertension, diabetes, cardiac, renal disease, hemophilia and bronchial asthma were excluded from the study. The efficacy of labetalol and nifedipine were compared. Results: In this study fall in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) in labetalol group was statistically significant when compared to nifedipine. Outcome of fetus was also better with use of oral labetalol. Conclusion: The present study indicates labetalol to be better antihypertensive in terms of control of hypertension and fetal outcome.

Keywords

• nifedipine
• labetalol
• pih
• preeclampsia