Evaluation Clinical Effects of Anti-Septic Solution Based on Propolis in Caries-Active Children

Abstract

Objective: This study aimed validate the action of one anti-septic solution based on propolis against the clinical indexes and levels of S. mutans. Method: The antimicrobial activity of the extract was done on solid plates to determinate the Minimum Inhibitory Concentration (MIC) using sorts of S. mutans. With the MIC of the extract, was made a mouthrinse solution of propolis (6.25%), which was used clinically as a test solution and compared with positive control solution, the chlorexidine (0.12%). Through the crossover design, fifteen children used the mouthrinse solution of propolis during 15 consecutive days and after a break of 21 days, they used daily mouthrinse with the chlorexidine. Were collected indexes for accumulation of oral biofilm (OHI-S) and for gun disease (GBI) before (T0) and 24 hours after (T1) the use of the solutions, besides of the couting of the S. mutans from saliva's samples before (T0) and 24 hours (T0), 7 days (T7), 15 days (T15) e 21 days (T21) after the end of both mouthrinses. Results: The results demonstrated significative reduction of the S. mutans levels 24 hours (p0.05). Conclusion: The propolis extract showed satisfactory antimicrobial activity and close to the chlorexidine's action, besides of act against clinical conditions of oral biofilm's presence and gun disease what becomes it useful as therapeutic agent.

Keywords

• Dental caries
• Propolis
• Streptococcus mutans