Nature Communications (Dec 2018)

Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty

  • Ryoji Sekine,
  • Tatsuo Shibata,
  • Miki Ebisuya

DOI
https://doi.org/10.1038/s41467-018-07847-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Nodal-Lefty signaling combines a short-range activator and a long-range inhibitor for axis formation and left-right patterning. Here the authors reconstitute a synthetic biology activator-inhibitor circuit of Nodal-Lefty to drive pattern formation in mammalian cells.