Nature Communications (Dec 2018)
Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty
Abstract
Nodal-Lefty signaling combines a short-range activator and a long-range inhibitor for axis formation and left-right patterning. Here the authors reconstitute a synthetic biology activator-inhibitor circuit of Nodal-Lefty to drive pattern formation in mammalian cells.