Nature Communications (Oct 2018)

Structural basis for PtdInsP2-mediated human TRPML1 regulation

  • Michael Fine,
  • Philip Schmiege,
  • Xiaochun Li

DOI
https://doi.org/10.1038/s41467-018-06493-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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Transient receptor potential mucolipin 1 (TRPML1) is a lysosomal channel which maintains the low pH and calcium levels for lysosomal function. Here authors use structural biology and electrophysiology to show how lipids bind and allosterically activate TRPML1.