EVALUATION OF EPIDEMIOLOGIC EFFECTIVENESS OF INFLUENZA INACTIVATED POLYMER-SUBUNIT VACCINE IN SCHOOLCHILDREN

Abstract

Present study was dedicated to the assessment of the «Grippol plus» polymer-subunit vaccine effectiveness in Moscow region’ Podolsk town schoolchildren in season 2008–2009. The study included 3203 participants (1950 vaccineers and 1253 non-vaccineers). Post-vaccination influenza and acute respiratory infections (ARIs) morbidity 6-months monitoring demonstrated high Grippol effectiveness. It was shown that vaccineers’ influenza morbidity rate was 4,7-times lower than in non-vaccinated schoolchildren. Immunized children’ ARIs morbidity was 1,4 times lower in comparison with other. Grippol effectiveness indexes were 4,7 и 78,7%. An important role for herd immunity protection was also demonstrated clearly by means of overall influenza and ARIs morbidity level decline. The schools with high vaccination coverage ( 60% of children) showed the overall morbidity rate 40% lower than that in schools with low immunization coverage.Key words: schoolchildren, influenza, ARI, vaccination, collective immunity.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(5):47-51)