Curcumin-Loaded Micelles Dispersed in Ureasil-Polyether Materials for a Novel Sustained-Release Formulation
Kammila Martins Nicolau Costa,
Mariana Rillo Sato,
Tellys Lins Almeida Barbosa,
Meiry Gláucia Freire Rodrigues,
Ana Cláudia Dantas Medeiros,
Bolívar Ponciano Goulart de Lima Damasceno,
João Augusto Oshiro-Júnior
Affiliations
Kammila Martins Nicolau Costa
Pharmaceutical Sciences Postgraduate Program, Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande 58429-600, Paraíba, Brazil
Mariana Rillo Sato
School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, São Paulo, Brazil
Tellys Lins Almeida Barbosa
Postgraduate Program in Chemical Engineering, Federal University of Campina Grande, Aprígio Veloso, 882, Campina Grande 58429-970, Paraíba, Brazil
Meiry Gláucia Freire Rodrigues
Postgraduate Program in Chemical Engineering, Federal University of Campina Grande, Aprígio Veloso, 882, Campina Grande 58429-970, Paraíba, Brazil
Ana Cláudia Dantas Medeiros
Pharmaceutical Sciences Postgraduate Program, Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande 58429-600, Paraíba, Brazil
Bolívar Ponciano Goulart de Lima Damasceno
Pharmaceutical Sciences Postgraduate Program, Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande 58429-600, Paraíba, Brazil
João Augusto Oshiro-Júnior
Pharmaceutical Sciences Postgraduate Program, Center for Biological and Health Sciences, State University of Paraíba, Av. Juvêncio Arruda, S/N, Campina Grande 58429-600, Paraíba, Brazil
Vulvovaginal candidiasis (VVC) is a vulvar/vaginal infection that affects approximately 75% of women worldwide. The current treatment consists of antimicrobials with hepatotoxic properties and high drug interaction probabilities. Therefore, this study aimed to develop a new treatment to VVC based on micelles containing curcumin (CUR) dispersed in a ureasil-polyether (U-PEO) hybrid. The physical-chemical characterization was carried out in order to observe size, shape, crystallinity degree and particle dispersion in the formulation and was performed by dynamic light scattering (DLS), scanning electron microscopy (SEM), X-ray diffraction (XRD) and through in vitro release study. The results of DLS and SEM exhibited micelles with 35 nm, and encapsulation efficiency (EE) results demonstrated 100% of EE to CUR dispersed in the U-PEO, which was confirmed by the DRX. The release results showed that CUR loaded in U-PEO is 70% released after 10 days, which demonstrates the potential application of this material in different pharmaceutical forms (ovules and rings), and the possibility of multidose based on a single application, suggesting a higher rate of adherence.
