Clinico Pathological Analysis of Uterine Serous Carcinoma in a Cancer Centre from Northern Kerala-A Retrospective Study

Abstract

Introduction: Uterine Serous Carcinoma (USC) accounts for 10% of malignancies of uterine corpus. They are characterised by high propensity for local spread, extra uterine metastasis, recurrence and are having poor prognosis. The disease can be highly aggressive even if it is confined to uterus at time of surgery. Aim: To assess the clinico-pathologic features of uterine serous carcinoma in patients of north Kerala and to analyse its predictors of outcome. Materials and Methods: Data of cases diagnosed with uterine serous carcinoma for five years from 2012 January to 2016 December were retrieved from medical library. Overall survival and progression free survival were assessed. Results: It is observed that all patients were post menopausal women with the age of 59.5+8.535 with predominant clinical presentation of vaginal bleeding. As per the FIGO staging, 13 patients were in Stage I, 11 cases were in Stage III, 4 cases were in IV and no cases reported in Stage II. Out of 28, 9 cases (32.1%) were died and 12 patients (42.8%) had recurrence during the follow-up period. 19 cases (67.9 %) had the five year over all survival. For stage I patients the overall survival was 76.9%, Stage III had 72.7%, and Stage IV had only 25%. 3 out of the 13 cases in Stage I, 6 out of 11 cases in Stage III and 3 out of 4 cases in Stage IV showed recurrence irrespective of the adjuvant treatment. Conclusion: Uterine serous carcinoma has distinct clinicopathologic features compared to the more common endometrioid carcinoma. It carries poor prognosis. Complete surgical staging with close follow-up is needed even in cases confined to uterus.

Keywords

• endometrial serous carcinoma
• prognosis
• surgical staging
• type ii endometrial carcinoma