Nature Communications (Mar 2019)

Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer

  • Elizabeth L. Christie,
  • Swetansu Pattnaik,
  • Jessica Beach,
  • Anthony Copeland,
  • Nineveh Rashoo,
  • Sian Fereday,
  • Joy Hendley,
  • Kathryn Alsop,
  • Samuel L. Brady,
  • Greg Lamb,
  • Ahwan Pandey,
  • Anna deFazio,
  • Heather Thorne,
  • Andrea Bild,
  • David D. L. Bowtell

DOI
https://doi.org/10.1038/s41467-019-09312-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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ABCB1 encodes Multidrug Resistance Protein which promotes efflux of chemotherapeutic and targeted agents. Here, in breast and ovarian cancer the authors identify multiple transcriptional fusion partners involving ABCB1 that are associated with treatment failure and previous treatment regimens.