Nature Communications (Jun 2022)
Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques
- Victoria E. K. Walker-Sperling,
- Noe B. Mercado,
- Abishek Chandrashekar,
- Erica N. Borducchi,
- Jinyan Liu,
- Joseph P. Nkolola,
- Mark Lewis,
- Jeffrey P. Murry,
- Yunling Yang,
- Romas Geleziunas,
- Merlin L. Robb,
- Nelson L. Michael,
- Maria G. Pau,
- Frank Wegmann,
- Hanneke Schuitemaker,
- Emily J. Fray,
- Mithra R. Kumar,
- Janet D. Siliciano,
- Robert F. Siliciano,
- Dan H. Barouch
Affiliations
- Victoria E. K. Walker-Sperling
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
- Noe B. Mercado
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
- Abishek Chandrashekar
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
- Erica N. Borducchi
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
- Jinyan Liu
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
- Joseph P. Nkolola
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
- Mark Lewis
- Bioqual
- Jeffrey P. Murry
- Gilead Sciences
- Yunling Yang
- Gilead Sciences
- Romas Geleziunas
- Gilead Sciences
- Merlin L. Robb
- US Military HIV Research Program, Walter Reed Army Institute of Research
- Nelson L. Michael
- US Military HIV Research Program, Walter Reed Army Institute of Research
- Maria G. Pau
- Janssen Vaccines & Prevention
- Frank Wegmann
- Janssen Vaccines & Prevention
- Hanneke Schuitemaker
- Janssen Vaccines & Prevention
- Emily J. Fray
- Department of Medicine, Johns Hopkins University School of Medicine
- Mithra R. Kumar
- Department of Medicine, Johns Hopkins University School of Medicine
- Janet D. Siliciano
- Department of Medicine, Johns Hopkins University School of Medicine
- Robert F. Siliciano
- Department of Medicine, Johns Hopkins University School of Medicine
- Dan H. Barouch
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-31196-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 8
Abstract
Antiretroviral therapy alone is insufficient in curing HIV-1 infection, due to latent viral reservoir persistency. Here, authors explore the post-virologic control of combining active and passive immunisation with vesatolimod, in a SHIV-infected rhesus macaque model.
