Nature Communications (Jan 2018)

Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

  • Jacqueline A. Maybin,
  • Alison A. Murray,
  • Philippa T. K. Saunders,
  • Nikhil Hirani,
  • Peter Carmeliet,
  • Hilary O. D. Critchley

DOI
https://doi.org/10.1038/s41467-017-02375-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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About a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential therapeutic strategy for this debilitating condition.