Nature Communications (Jan 2018)
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation
Abstract
About a quarter of pre-menopausal women will suffer from heavy menstrual bleeding in their lives. Here, Maybin and colleagues show hypoxia and subsequent activation of HIF-1α during menses are required for normal endometrial repair, and identify pharmacological stabilisation of HIF-1α as a potential therapeutic strategy for this debilitating condition.