Frontiers in Medicine (Dec 2020)
Morphologic Features of Myopic Choroidal Neovascularization in Pathologic Myopia on Swept-Source Optical Coherence Tomography
- Jiamin Xie,
- Jiamin Xie,
- Jiamin Xie,
- Jiamin Xie,
- Jiamin Xie,
- Jiamin Xie,
- Qiuying Chen,
- Qiuying Chen,
- Qiuying Chen,
- Qiuying Chen,
- Qiuying Chen,
- Qiuying Chen,
- Jiayi Yu,
- Jiayi Yu,
- Jiayi Yu,
- Jiayi Yu,
- Jiayi Yu,
- Jiayi Yu,
- Hao Zhou,
- Hao Zhou,
- Hao Zhou,
- Hao Zhou,
- Hao Zhou,
- Jiangnan He,
- Weijun Wang,
- Weijun Wang,
- Weijun Wang,
- Weijun Wang,
- Weijun Wang,
- Ying Fan,
- Ying Fan,
- Ying Fan,
- Ying Fan,
- Ying Fan,
- Ying Fan,
- Xun Xu,
- Xun Xu,
- Xun Xu,
- Xun Xu,
- Xun Xu,
- Xun Xu
Affiliations
- Jiamin Xie
- Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jiamin Xie
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Jiamin Xie
- Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China
- Jiamin Xie
- Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China
- Jiamin Xie
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Jiamin Xie
- Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China
- Qiuying Chen
- Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Qiuying Chen
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Qiuying Chen
- Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China
- Qiuying Chen
- Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China
- Qiuying Chen
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Qiuying Chen
- Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China
- Jiayi Yu
- Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jiayi Yu
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Jiayi Yu
- Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China
- Jiayi Yu
- Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China
- Jiayi Yu
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Jiayi Yu
- Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China
- Hao Zhou
- Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Hao Zhou
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Hao Zhou
- Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China
- Hao Zhou
- Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China
- Hao Zhou
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Jiangnan He
- Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China
- Weijun Wang
- Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Weijun Wang
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Weijun Wang
- Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China
- Weijun Wang
- Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China
- Weijun Wang
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Ying Fan
- Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Ying Fan
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Ying Fan
- Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China
- Ying Fan
- Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China
- Ying Fan
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Ying Fan
- Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China
- Xun Xu
- Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Xun Xu
- National Clinical Research Center for Eye Diseases, Shanghai, China
- Xun Xu
- Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China
- Xun Xu
- Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China
- Xun Xu
- Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China
- Xun Xu
- Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China
- DOI
- https://doi.org/10.3389/fmed.2020.615902
- Journal volume & issue
-
Vol. 7
Abstract
Purpose: To investigate the morphologic features and identify the risk factors of myopic choroidal neovascularization (CNV).Methods: Eighty-eight eyes of 69 consecutive patients with myopic CNV were included in this study. About 109 eyes of 78 pathologic myopia patients without myopic CNV were randomly selected as the control group. Morphologic features and parameters including scleral thickness (ST), choroidal thickness (CT), posterior staphyloma height and the presence of scleral perforating vessels were obtained and measured by swept-source optical coherence tomography (SS-OCT). Binary logistic regression analysis was performed to identify the risk factors for myopic CNV.Results: Patients with myopic CNV had relatively shorter axial length (P < 0.001) and thicker sclera (P < 0.001) compared to those without. After adjusting age, gender and axial length, thick sclera (OR = 1.333, P < 0.001 per 10-μm increase) and thin choroid (OR = 0.509, P < 0.001 per 10-μm increase) were associated with the presence of myopic CNV. Scleral perforating vessels were detected in the area of myopic CNV in 78.67% of the subjects.Conclusions: A relatively thicker sclera and a thinner choroid are the biological indicators for myopic CNV on SS-OCT. Scleral perforating vessels may also play a pivotal role in the formation of myopic CNV.
Keywords
- choroidal thickness
- myopic choroidal neovascularization
- scleral thickness
- scleral perforating vessels
- pathologic myopia
