Nature Communications (Jun 2016)
LRP6 acts as a scaffold protein in cardiac gap junction assembly
- Jun Li,
- Changming Li,
- Dandan Liang,
- Fei Lv,
- Tianyou Yuan,
- Erlinda The,
- Xiue Ma,
- Yahan Wu,
- Lixiao Zhen,
- Duanyang Xie,
- Shiyi Wang,
- Yuan Liu,
- Jian Huang,
- Jingyi Shi,
- Yi Liu,
- Dan Shi,
- Liang Xu,
- Li Lin,
- Luying Peng,
- Jianmin Cui,
- Weidong Zhu,
- Yi-Han Chen
Affiliations
- Jun Li
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Changming Li
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Dandan Liang
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Fei Lv
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Tianyou Yuan
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Erlinda The
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Xiue Ma
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Yahan Wu
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Lixiao Zhen
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Duanyang Xie
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Shiyi Wang
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Yuan Liu
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Jian Huang
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Jingyi Shi
- and Department of Biomedical Engineering, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Yi Liu
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Dan Shi
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Liang Xu
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Li Lin
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Luying Peng
- Department of Pathology and Pathophysiology, Tongji University School of Medicine
- Jianmin Cui
- and Department of Biomedical Engineering, Cardiac Bioelectricity and Arrhythmia Center, Washington University
- Weidong Zhu
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- Yi-Han Chen
- Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms11775
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts.
