Nature Communications (Nov 2017)

The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis

  • Mitsuaki Fujimoto,
  • Ryosuke Takii,
  • Eiichi Takaki,
  • Arpit Katiyar,
  • Ryuichiro Nakato,
  • Katsuhiko Shirahige,
  • Akira Nakai

DOI
https://doi.org/10.1038/s41467-017-01807-7
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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PARP1 recruitment to DNA lesions is critical for DNA damage repair but how DNA damage induces PARP1 redistribution is largely unknown. Here, the authors provide evidence that PARP1 redistribution and DNA repair in tumor cells depend on the formation of a HSF1–PARP13–PARP1 complex.