Regulation of neuronal plasticity associated with neuropsychiatric disorders by the orexinergic system
Fei Cao,
Zhengyang Guo,
Xiaodan Ma,
Xuezhi Li,
Qinqin Wang
Affiliations
Fei Cao
Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Jining Key Laboratory of Cognitive Disorder, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, 272013, China
Zhengyang Guo
Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Jining Key Laboratory of Cognitive Disorder, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, 272013, China
Xiaodan Ma
Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Jining Key Laboratory of Cognitive Disorder, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, 272013, China
Xuezhi Li
Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Jining Key Laboratory of Cognitive Disorder, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, 272013, China; Corresponding author. Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China.
Qinqin Wang
Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Shandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China; Jining Key Laboratory of Cognitive Disorder, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, 272013, China; Corresponding author. Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jianshe South Road No.45, Rencheng District, Jining, Shandong, 272013, China.
Orexins are a family of neuropeptides secreted by neurons in the lateral hypothalamus (LH). These peptides act widespreadly across the body by interacting with specific orexin receptors on target cells, which comprise the orexinergic system. Emerging evidence has revealed that the orexinergic system is tightly associated with neuropsychiatric disorders; however, the underlying mechanisms require further exploration. Neuropsychiatric disorders have also been associated with neuroplasticity, while orexins have been shown to play regulatory roles in neuronal plasticity. As such, this review aims to summarize the recent progress of research investigating the roles of the orexinergic system in neuronal plasticity and associated neuropsychiatric disorders, including addiction, depression, and schizophrenia, which may provide novel insights into the mechanism of the orexinergic system in the pathogenesis of these neuropsychiatric disorders.
