<i>Bacillus anthracis</i> Siderophores

Abstract

Iron is an essential for growth and reproduction of bacteria element. One of the ways of its acquisition by Bacillus anthracis is utilization of high-affinity chelating agents of iron ions - bacillibactin and petrobactin siderophores, extracting the iron from transferring and ferritin of a host cell. Bacillibactin and petrobactin functions are realized on different stages of B. anthracis growth in vivo, whereas petrobactin synthesis is also necessary for manifestation of microbe virulence. Awareness of siderophore biosynthesis pathways facilitates the development of medicines against anthrax, which can block them up. The review contains the data on the structure, genetics, and functions of B. anthracis siderophores.

Keywords

• сидерофоры
• потребление железа
• вирулентность b anthracis
• siderophores
• iron acquisition
• b anthracis virulence