Frontiers in Immunology (Feb 2023)

Inhibition of tumor necrosis factor receptor 1 and the risk of periodontitis

  • Zoheir Alayash,
  • Sebastian-Edgar Baumeister,
  • Birte Holtfreter,
  • Thomas Kocher,
  • Hansjörg Baurecht,
  • Benjamin Ehmke,
  • Stefan Lars Reckelkamm,
  • Michael Nolde

DOI
https://doi.org/10.3389/fimmu.2023.1094175
Journal volume & issue
Vol. 14

Abstract

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AimTo investigate the effect of genetically proxied inhibition of tumor necrosis factor receptor 1 (TNFR1) on the risk of periodontitis.Materials and methodsGenetic instruments were selected from the vicinity of TNFR superfamily member 1A (TNFRSF1A) gene (chromosome 12; base pairs 6,437,923–6,451,280 as per GRCh37 assembly) based on their association with C-reactive protein (N= 575,531). Summary statistics of these variants were obtained from a genome-wide association study (GWAS) of 17,353 periodontitis cases and 28,210 controls to estimate the effect of TNFR1 inhibition on periodontitis using a fixed-effects inverse method.ResultsConsidering rs1800693 as an instrument, we found no effect of TNFR1 inhibition on periodontitis risk (Odds ratio (OR) scaled per standard deviation increment in CRP: 1.57, 95% confidence interval (CI): 0.38;6.46). Similar results were derived from a secondary analysis that used three variants (rs767455, rs4149570, and rs4149577) to index TNFR1 inhibition.ConclusionsWe found no evidence of a potential efficacy of TNFR1 inhibition on periodontitis risk.

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