Antifungal Activity of <i>Aniba canelilla</i> (Kunth) Mez Essential Oil and Its Main Compound 1-Nitro-2-Phenylethane against Dermatophytes
Tainá Kreutz,
Eliane Oliveira Salines Duarte,
Priscilla Maciel Quatrin,
Simone Braga Carneiro,
Valdir F. Veiga-Junior,
Alexandre Meneghello Fuentefria,
Letícia S. Koester
Affiliations
Tainá Kreutz
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil
Eliane Oliveira Salines Duarte
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil
Priscilla Maciel Quatrin
Programa de Pós-Graduação em Microbiologia Agrícola e do Ambiente, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil
Simone Braga Carneiro
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal do Amazonas, Av. Gal. Rodrigo Octávio, Japiim, 6200, Manaus 69079-000, Amazonas, Brazil
Valdir F. Veiga-Junior
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal do Amazonas, Av. Gal. Rodrigo Octávio, Japiim, 6200, Manaus 69079-000, Amazonas, Brazil
Alexandre Meneghello Fuentefria
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil
Letícia S. Koester
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil
The essential oil of Aniba canelilla (Kunth) Mez (EOAC), an Amazon plant composed of a rare nitro compound, has shown scientific evidence of antifungal activity but is still unexplored against dermatophytes. The antifungal susceptibility of EOAC and its main compound, 1-nitro-2-phenylethane (NP), was evaluated against dermatophytes (Trichophyton rubrum, T. mentagrophytes and Microsporum canis), evidencing antifungal activity with an inhibitory concentration lower than 256 μg/mL. The mechanism of action was also evaluated, and it is suggested that EOAC and NP have fungicidal action in the fungal membrane, since the antifungal activity occurs through a modification of the shape of the conidial structures of the fungus, showing the permeability of the intracellular content due to the visually observed plasmolysis and cytosolic extravasation through an osmotic process. These results suggest the essential oil and its main compound are promising plant-derived alternatives for treating ungual dermatophytosis.
