Correlation analysis between Scr，hs-cTnT，NT-proBNP and major cardiovascular adverse events in patients with burn injury

Abstract

Objective To investigate the correlation between serum creatinine（Scr），high-sensitivity troponin T（hs-cTnT），N-terminal pro-B-type natriuretic peptide（NT-proBNP），and in-hospital major adverse cardiovascular events（MACE）in burn patients and evaluate their predictive value. Methods In this retrospective study，254 burn patients were enrolled and divided into the MACE group（n = 85）and non-MACE group（n = 169）according to whether MACE occurred during hospital stay. Clinical baseline data and laboratory indexes were statistically compared between the two groups. The predictive values of Scr，hs-cTnT，and NT-proBNP for in-hospital MACE in burn patients were assessed by the receiver operating characteristic（ROC）curve. Results Compared with the non-MACE group，older age，larger total area of burns，and higher levels of Scr，hs-cTnT，NT-proBNP，and cystatin C were observed in the MACE group（all P < 0.05）. There were significant differences in gender，history of hypertension，sepsis，and smoking history between the two groups（all P < 0.05）. Multivariate analysis showed that Scr，hs-cTnT，and NT-proBNP were the independent risk factors for nosocomial MACE in burn patients（all P < 0.05）. The area under the curve（AUC）values of Scr，hs-cTnT，NT-proBNP，and their combined prediction of MACE were 0.743，0.802，0.733，and 0.801 by ROC curve analysis. According to the DeLong test results，the AUC value of MACE predicted by the three combined was more significant than the value indicated by Scr alone（Z value = 2.897，P = 0.003）. The predictive value of Scr，hs-cTnT，and NT-proBNP for MACE was not significantly different（Z values were 1.398，0.202，and 1.900，and P values were 0.162，0.840，and 0.057，respectively）. Subgroup analysis showed that the incidence of MACE in burn patients in the hs-cTnT≥0.014 5 μg/L group was higher than in their counterparts in the hs-cTnT < 0.014 5 μg/L group（P < 0.05）. Spearman correlation analysis showed a positive correlation between hs-cTnT level and the severity of burns（P < 0.05）. Conclusions Scr，hs-cTnT，and NT-proBNP are the independent risk factors for nosocomial MACE in burn patients and have good predictive values. In addition，hs-cTnT level is correlated with the severity of burns.

Keywords

• burn|major adverse cardiovascular event|serum creatinine|high-sensitivity troponin t|n-terminal pro-b-type natriuretic peptide