Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis

Wen-Ching Shen; Yung-Chih Lai; Ling-Hui Li; Kolin Liao; Hung-Chang Lai; Shou-Yen Kao; John Wang; Cheng-Ming Chuong; Shih-Chieh Hung

doi:10.1038/s41467-019-10197-x

Nature Communications (May 2019)

Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis

Wen-Ching Shen,
Yung-Chih Lai,
Ling-Hui Li,
Kolin Liao,
Hung-Chang Lai,
Shou-Yen Kao,
John Wang,
Cheng-Ming Chuong,
Shih-Chieh Hung

Affiliations

Wen-Ching Shen: Drug Development Center, Institute of New Drug Development, Institute of Biomedical Sciences, China Medical University
Yung-Chih Lai: Integrative Stem Cell Center, Department of Orthopaedics, China Medical University Hospital
Ling-Hui Li: Institute of Biomedical Sciences, Academia Sinica
Kolin Liao: Drug Development Center, Institute of New Drug Development, Institute of Biomedical Sciences, China Medical University
Hung-Chang Lai: Department of Stomatology, Taipei Veterans General Hospital
Shou-Yen Kao: Department of Stomatology, Taipei Veterans General Hospital
John Wang: Department of Pathology, China Medical University Hospital
Cheng-Ming Chuong: Integrative Stem Cell Center, Department of Orthopaedics, China Medical University Hospital
Shih-Chieh Hung: Drug Development Center, Institute of New Drug Development, Institute of Biomedical Sciences, China Medical University

DOI: https://doi.org/10.1038/s41467-019-10197-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Mesenchymal stem cells derived from dental pulp (DP-MSCs) differ in oncogenesic and developmental potential compared to those from bone marrow. Here, the authors show that decreased DNA methylation and histone H3K9Me2 enrichment along with higher PTEN activation in DP-MSCs promotes osteogenesis and reduces oncogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal