Dementia with Lewy bodies post-mortem brains reveal differentially methylated CpG sites with biomarker potential

Xiaojian Shao; Sangeetha Vishweswaraiah; Miroslava Čuperlović-Culf; Ali Yilmaz; Celia M. T. Greenwood; Anuradha Surendra; Bernadette McGuinness; Peter Passmore; Patrick G. Kehoe; Michael E. Maddens; Steffany A. L. Bennett; Brian D. Green; Uppala Radhakrishna; Stewart F. Graham

doi:10.1038/s42003-022-03965-x

Communications Biology (Nov 2022)

Dementia with Lewy bodies post-mortem brains reveal differentially methylated CpG sites with biomarker potential

Xiaojian Shao,
Sangeetha Vishweswaraiah,
Miroslava Čuperlović-Culf,
Ali Yilmaz,
Celia M. T. Greenwood,
Anuradha Surendra,
Bernadette McGuinness,
Peter Passmore,
Patrick G. Kehoe,
Michael E. Maddens,
Steffany A. L. Bennett,
Brian D. Green,
Uppala Radhakrishna,
Stewart F. Graham

Affiliations

Xiaojian Shao: National Research Council of Canada, Digital Technologies Research Centre
Sangeetha Vishweswaraiah: Oakland University-William Beaumont School of Medicine
Miroslava Čuperlović-Culf: National Research Council of Canada, Digital Technologies Research Centre
Ali Yilmaz: Oakland University-William Beaumont School of Medicine
Celia M. T. Greenwood: Lady Davis Institute for Medical Research, Jewish General Hospital
Anuradha Surendra: National Research Council of Canada, Digital Technologies Research Centre
Bernadette McGuinness: Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast
Peter Passmore: Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast
Patrick G. Kehoe: Dementia Research Group, Translational Health Sciences, Bristol Medical School, University of Bristol
Michael E. Maddens: Oakland University-William Beaumont School of Medicine
Steffany A. L. Bennett: Ottawa Institute of Systems Biology
Brian D. Green: Institute for Global Food Security, School of Biological Sciences, Faculty of Medicine, Health and Life Sciences, Queen’s University Belfast
Uppala Radhakrishna: Oakland University-William Beaumont School of Medicine
Stewart F. Graham: Oakland University-William Beaumont School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03965-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

Read online

Post-mortem brain tissue from patients with Dementia with Lewy bodies shows differentially methylated CpG sites and potential epigenetic associations with other conditions such as mood disorders and Parkinson’s Disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal