Endogenous antibody response to SARS-CoV-2 in patients who received monoclonal antibodies against COVID-19: A systematic review

Andrea Lombardi; Cecilia Azzarà; Giulia Renisi; Giulia Viero; Andrea Gori; Alessandra Bandera

Clinical Immunology Communications (Dec 2022)

Endogenous antibody response to SARS-CoV-2 in patients who received monoclonal antibodies against COVID-19: A systematic review

Andrea Lombardi,
Cecilia Azzarà,
Giulia Renisi,
Giulia Viero,
Andrea Gori,
Alessandra Bandera

Affiliations

Andrea Lombardi: Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Corresponding author at: Department of Pathophysiology and Transplantation, via Francesco Sforza 35, University of Milan, Milan, Italy
Cecilia Azzarà: Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
Giulia Renisi: Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
Giulia Viero: Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
Andrea Gori: Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Alessandra Bandera: Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Corresponding author at: Department of Pathophysiology and Transplantation, via Francesco Sforza 35, University of Milan, Milan, Italy

Journal volume & issue: Vol. 2
pp. 106 – 109

Abstract

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Passive immunization with mAbs has been employed in COVID-19. We performed a systematic review of the literature assessing the endogenous humoral immune response against SARS-CoV-2 in patients treated with mAbs. Administration of mAbs in seronegative patients led to a reduction in both antibody titres and neutralizing activity against the virus.

Published in Clinical Immunology Communications

ISSN: 2772-6134 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.journals.elsevier.com/clinical-immunology-communications

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