Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1

Stephan Kiontke; Lars Langemeyer; Anne Kuhlee; Saskia Schuback; Stefan Raunser; Christian Ungermann; Daniel Kümmel

doi:10.1038/ncomms14034

Nature Communications (Jan 2017)

Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1

Stephan Kiontke,
Lars Langemeyer,
Anne Kuhlee,
Saskia Schuback,
Stefan Raunser,
Christian Ungermann,
Daniel Kümmel

Affiliations

Stephan Kiontke: Division of Structural Biology, Department of Biology/Chemistry, University of Osnabrück
Lars Langemeyer: Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück
Anne Kuhlee: Department of Structural Biochemistry, Max-Planck-Institute of Molecular Physiology
Saskia Schuback: Division of Structural Biology, Department of Biology/Chemistry, University of Osnabrück
Stefan Raunser: Department of Structural Biochemistry, Max-Planck-Institute of Molecular Physiology
Christian Ungermann: Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück
Daniel Kümmel: Division of Structural Biology, Department of Biology/Chemistry, University of Osnabrück

DOI: https://doi.org/10.1038/ncomms14034
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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The Mon1-Ccz1 (MC1) complex is a Rab guanine nucleotide exchange factor (RabGEF) for Ypt7/Rab7 important for endosomal maturation. Here the authors present the biochemical and structural characterization of MC1, elucidating its catalytic mechanism and showing that MC1 represents novel class of RabGEFs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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