IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition

• Bruno Alicke,
• Eugene Varfolomeev,
• Shi Hui Kaylee Lee,
• Alexandra Frommlet,
• Savita Ubhayakar,
• John G. Quinn,
• Wayne J. Fairbrother,
• Robert Jones,
• Stephen E. Gould,
• Domagoj Vucic

Affiliations

Bruno Alicke

Departments of In Vivo Pharmacology, Genentech

Eugene Varfolomeev

Immunology Discovery, Genentech

Shi Hui Kaylee Lee

Drug Metabolism and Pharmacokinetics, Genentech

Alexandra Frommlet

Biochemical and Cellular Pharmacology, Genentech

Savita Ubhayakar

Drug Metabolism and Pharmacokinetics, Genentech

John G. Quinn

Biochemical and Cellular Pharmacology, Genentech

Wayne J. Fairbrother

Early Discovery Biochemistry, Genentech

Robert Jones

Drug Metabolism and Pharmacokinetics, Genentech

Stephen E. Gould

Departments of In Vivo Pharmacology, Genentech

Domagoj Vucic

Immunology Discovery, Genentech