Nature Communications (Oct 2016)
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria
- Pierre-Yves Mantel,
- Daisy Hjelmqvist,
- Michael Walch,
- Solange Kharoubi-Hess,
- Sandra Nilsson,
- Deepali Ravel,
- Marina Ribeiro,
- Christof Grüring,
- Siyuan Ma,
- Prasad Padmanabhan,
- Alexander Trachtenberg,
- Johan Ankarklev,
- Nicolas M. Brancucci,
- Curtis Huttenhower,
- Manoj T. Duraisingh,
- Ionita Ghiran,
- Winston P. Kuo,
- Luis Filgueira,
- Roberta Martinelli,
- Matthias Marti
Affiliations
- Pierre-Yves Mantel
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Daisy Hjelmqvist
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Michael Walch
- Department of Medicine, Unit of Anatomy, University of Fribourg
- Solange Kharoubi-Hess
- Department of Medicine, Unit of Anatomy, University of Fribourg
- Sandra Nilsson
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Deepali Ravel
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Marina Ribeiro
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Christof Grüring
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Siyuan Ma
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Prasad Padmanabhan
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Alexander Trachtenberg
- Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School
- Johan Ankarklev
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Nicolas M. Brancucci
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Curtis Huttenhower
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Manoj T. Duraisingh
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Ionita Ghiran
- Division of Allergy and Infection, Beth Israel Deaconess Medical Center
- Winston P. Kuo
- Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School
- Luis Filgueira
- Department of Medicine, Unit of Anatomy, University of Fribourg
- Roberta Martinelli
- Center for Vascular Biology Research, Beth Israel Deaconess Medical Center
- Matthias Marti
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- DOI
- https://doi.org/10.1038/ncomms12727
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Inflammatory response to malaria pathogen Plasmodium falciparumcan be triggered by infected red blood cell-derived extracellular vesicles (EVs). This study shows these EVs contain functional microRNA-Argonaute 2 complex that modulates gene expression and alter vascular barrier properties.
