Nature Communications (May 2022)
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity
- Wuji Zhang,
- Brendon Y. Chua,
- Kevin J. Selva,
- Lukasz Kedzierski,
- Thomas M. Ashhurst,
- Ebene R. Haycroft,
- Suzanne K. Shoffner-Beck,
- Luca Hensen,
- David F. Boyd,
- Fiona James,
- Effie Mouhtouris,
- Jason C. Kwong,
- Kyra Y. L. Chua,
- George Drewett,
- Ana Copaescu,
- Julie E. Dobson,
- Louise C. Rowntree,
- Jennifer R. Habel,
- Lilith F. Allen,
- Hui-Fern Koay,
- Jessica A. Neil,
- Matthew J. Gartner,
- Christina Y. Lee,
- Patiyan Andersson,
- Sadid F. Khan,
- Luke Blakeway,
- Jessica Wisniewski,
- James H. McMahon,
- Erica E. Vine,
- Anthony L. Cunningham,
- Jennifer Audsley,
- Irani Thevarajan,
- Torsten Seemann,
- Norelle L. Sherry,
- Fatima Amanat,
- Florian Krammer,
- Sarah L. Londrigan,
- Linda M. Wakim,
- Nicholas J. C. King,
- Dale I. Godfrey,
- Laura K. Mackay,
- Paul G. Thomas,
- Suellen Nicholson,
- Kelly B. Arnold,
- Amy W. Chung,
- Natasha E. Holmes,
- Olivia C. Smibert,
- Jason A. Trubiano,
- Claire L. Gordon,
- Thi H. O. Nguyen,
- Katherine Kedzierska
Affiliations
- Wuji Zhang
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Brendon Y. Chua
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Kevin J. Selva
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Lukasz Kedzierski
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Thomas M. Ashhurst
- Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney
- Ebene R. Haycroft
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Suzanne K. Shoffner-Beck
- Department of Biomedical Engineering, University of Michigan
- Luca Hensen
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- David F. Boyd
- Department of Immunology, St Jude Children’s Research Hospital
- Fiona James
- Department of Infectious Diseases, Austin Health
- Effie Mouhtouris
- Department of Infectious Diseases, Austin Health
- Jason C. Kwong
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Kyra Y. L. Chua
- Department of Infectious Diseases, Austin Health
- George Drewett
- Department of Infectious Diseases, Austin Health
- Ana Copaescu
- Department of Infectious Diseases, Austin Health
- Julie E. Dobson
- Department of Radiology, Austin Health
- Louise C. Rowntree
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Jennifer R. Habel
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Lilith F. Allen
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Hui-Fern Koay
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Jessica A. Neil
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Matthew J. Gartner
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Christina Y. Lee
- Department of Biomedical Engineering, University of Michigan
- Patiyan Andersson
- Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Sadid F. Khan
- Department of Infectious Diseases, Monash University and Alfred Hospital
- Luke Blakeway
- Department of Infectious Diseases, Monash University and Alfred Hospital
- Jessica Wisniewski
- Department of Infectious Diseases, Monash University and Alfred Hospital
- James H. McMahon
- Department of Infectious Diseases, Monash University and Alfred Hospital
- Erica E. Vine
- Centre for Virus Research, The Westmead Institute for Medical Research
- Anthony L. Cunningham
- Centre for Virus Research, The Westmead Institute for Medical Research
- Jennifer Audsley
- Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Irani Thevarajan
- Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Torsten Seemann
- Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity
- Norelle L. Sherry
- Department of Infectious Diseases, Austin Health
- Fatima Amanat
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Florian Krammer
- Department of Microbiology, Icahn School of Medicine at Mount Sinai
- Sarah L. Londrigan
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Linda M. Wakim
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Nicholas J. C. King
- Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney
- Dale I. Godfrey
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Laura K. Mackay
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Paul G. Thomas
- Department of Immunology, St Jude Children’s Research Hospital
- Suellen Nicholson
- Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity
- Kelly B. Arnold
- Department of Biomedical Engineering, University of Michigan
- Amy W. Chung
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Natasha E. Holmes
- Department of Infectious Diseases, Austin Health
- Olivia C. Smibert
- Department of Infectious Diseases, Austin Health
- Jason A. Trubiano
- Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health
- Claire L. Gordon
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Thi H. O. Nguyen
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- Katherine Kedzierska
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne
- DOI
- https://doi.org/10.1038/s41467-022-30088-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
The immune response to SARS-CoV-2 infection is variable but has been linked to prognosis and the development of severe immunopathology. Here the authors assess a range of immune parameters in both peripheral blood and respiratory samples, providing a comparative assessment of the immune response between these compartments and their potential impact on immune-pathogenesis.
