International Journal of Molecular Sciences (Aug 2018)
rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology
- Linda E. Kelemen,
- Madalene Earp,
- Brooke L. Fridley,
- Georgia Chenevix-Trench,
- on behalf of Australian Ovarian Cancer Study Group,
- Peter A. Fasching,
- Matthias W. Beckmann,
- Arif B. Ekici,
- Alexander Hein,
- Diether Lambrechts,
- Sandrina Lambrechts,
- Els Van Nieuwenhuysen,
- Ignace Vergote,
- Mary Anne Rossing,
- Jennifer A. Doherty,
- Jenny Chang-Claude,
- Sabine Behrens,
- Kirsten B. Moysich,
- Rikki Cannioto,
- Shashikant Lele,
- Kunle Odunsi,
- Marc T. Goodman,
- Yurii B. Shvetsov,
- Pamela J. Thompson,
- Lynne R. Wilkens,
- Thilo Dörk,
- Natalia Antonenkova,
- Natalia Bogdanova,
- Peter Hillemanns,
- Ingo B. Runnebaum,
- Andreas du Bois,
- Philipp Harter,
- Florian Heitz,
- Ira Schwaab,
- Ralf Butzow,
- Liisa M. Pelttari,
- Heli Nevanlinna,
- Francesmary Modugno,
- Robert P. Edwards,
- Joseph L. Kelley,
- Roberta B. Ness,
- Beth Y. Karlan,
- Jenny Lester,
- Sandra Orsulic,
- Christine Walsh,
- Susanne K. Kjaer,
- Allan Jensen,
- Julie M. Cunningham,
- Robert A. Vierkant,
- Graham G. Giles,
- Fiona Bruinsma,
- Melissa C. Southey,
- Michelle A.T. Hildebrandt,
- Dong Liang,
- Karen Lu,
- Xifeng Wu,
- Thomas A. Sellers,
- Douglas A. Levine,
- Joellen M. Schildkraut,
- Edwin S. Iversen,
- Kathryn L. Terry,
- Daniel W. Cramer,
- Shelley S. Tworoger,
- Elizabeth M. Poole,
- Elisa V. Bandera,
- Sara H. Olson,
- Irene Orlow,
- Liv Cecilie Vestrheim Thomsen,
- Line Bjorge,
- Camilla Krakstad,
- Ingvild L. Tangen,
- Lambertus A. Kiemeney,
- Katja K.H. Aben,
- Leon F.A.G. Massuger,
- Anne M. van Altena,
- Tanja Pejovic,
- Yukie Bean,
- Melissa Kellar,
- Linda S. Cook,
- Nhu D. Le,
- Angela Brooks-Wilson,
- Jacek Gronwald,
- Cezary Cybulski,
- Anna Jakubowska,
- Jan Lubiński,
- Nicolas Wentzensen,
- Louise A. Brinton,
- Jolanta Lissowska,
- Estrid Hogdall,
- Svend Aage Engelholm,
- Claus Hogdall,
- Lene Lundvall,
- Lotte Nedergaard,
- Paul D.P. Pharoah,
- Ed Dicks,
- Honglin Song,
- Jonathan P. Tyrer,
- Iain McNeish,
- Nadeem Siddiqui,
- Karen Carty,
- Rosalind Glasspool,
- James Paul,
- Ian G. Campbell,
- Diana Eccles,
- Alice S. Whittemore,
- Valerie McGuire,
- Joseph H. Rothstein,
- Weiva Sieh,
- Steven A. Narod,
- Catherine M. Phelan,
- John R. McLaughlin,
- Harvey A. Risch,
- Hoda Anton-Culver,
- Argyrios Ziogas,
- Usha Menon,
- Simon A. Gayther,
- Aleksandra Gentry-Maharaj,
- Susan J. Ramus,
- Anna H. Wu,
- Celeste Leigh Pearce,
- Alice W. Lee,
- Malcolm C. Pike,
- Jolanta Kupryjanczyk,
- Agnieszka Podgorska,
- Joanna Plisiecka-Halasa,
- Wlodzimierz Sawicki,
- Ellen L. Goode,
- Andrew Berchuck,
- Ovarian Cancer Association Consortium
Affiliations
- Linda E. Kelemen
- Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
- Madalene Earp
- Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
- Brooke L. Fridley
- Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 USA
- Georgia Chenevix-Trench
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
- on behalf of Australian Ovarian Cancer Study Group
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
- Peter A. Fasching
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center, 91054 Erlangen, Germany
- Matthias W. Beckmann
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center, 91054 Erlangen, Germany
- Arif B. Ekici
- Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Erlangen 91054, Germany
- Alexander Hein
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center, 91054 Erlangen, Germany
- Diether Lambrechts
- Vesalius Research Center, University of Leuven, Leuven 3001, Belgium
- Sandrina Lambrechts
- Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium
- Els Van Nieuwenhuysen
- Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium
- Ignace Vergote
- Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven 3000, Belgium
- Mary Anne Rossing
- Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Jennifer A. Doherty
- Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA
- Jenny Chang-Claude
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany
- Sabine Behrens
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany
- Kirsten B. Moysich
- Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
- Rikki Cannioto
- Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
- Shashikant Lele
- Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
- Kunle Odunsi
- Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
- Marc T. Goodman
- Department of Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
- Yurii B. Shvetsov
- Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
- Pamela J. Thompson
- Department of Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
- Lynne R. Wilkens
- Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
- Thilo Dörk
- Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany
- Natalia Antonenkova
- Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk 223040, Belarus
- Natalia Bogdanova
- Gynaecology Research Unit, Hannover Medical School, Hannover 30625, Germany
- Peter Hillemanns
- Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover 30625, Germany
- Ingo B. Runnebaum
- Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena 07743, Germany
- Andreas du Bois
- Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Essen 45136, Germany
- Philipp Harter
- Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Essen 45136, Germany
- Florian Heitz
- Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte (KEM), Essen 45136, Germany
- Ira Schwaab
- Praxis für Humangenetik, Wiesbaden 65187, Germany
- Ralf Butzow
- Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland
- Liisa M. Pelttari
- Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland
- Heli Nevanlinna
- Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki 00290, Finland
- Francesmary Modugno
- Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
- Robert P. Edwards
- Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
- Joseph L. Kelley
- Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
- Roberta B. Ness
- School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA
- Beth Y. Karlan
- Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
- Jenny Lester
- Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
- Sandra Orsulic
- Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
- Christine Walsh
- Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
- Susanne K. Kjaer
- Department of Gynaecology, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark
- Allan Jensen
- Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Centre, DK-2100 Copenhagen, Denmark
- Julie M. Cunningham
- Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN 55905, USA
- Robert A. Vierkant
- Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA
- Graham G. Giles
- Centre for Epidemiology and Biostatistics, University of Melbourne, VIC 3010, Australia
- Fiona Bruinsma
- Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC 3004, Australia
- Melissa C. Southey
- Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia
- Michelle A.T. Hildebrandt
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
- Dong Liang
- College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA
- Karen Lu
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
- Xifeng Wu
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
- Thomas A. Sellers
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- Douglas A. Levine
- Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA
- Joellen M. Schildkraut
- Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908, USA
- Edwin S. Iversen
- Department of Statistical Science, Duke University, Durham, NC 27708, USA
- Kathryn L. Terry
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
- Daniel W. Cramer
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
- Shelley S. Tworoger
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- Elizabeth M. Poole
- Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
- Elisa V. Bandera
- Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA
- Sara H. Olson
- Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY 10065, USA
- Irene Orlow
- Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY 10065, USA
- Liv Cecilie Vestrheim Thomsen
- Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway
- Line Bjorge
- Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway
- Camilla Krakstad
- Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway
- Ingvild L. Tangen
- Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen 5021, Norway
- Lambertus A. Kiemeney
- Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen 6525 EZ, The Netherlands
- Katja K.H. Aben
- Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen 6525 EZ, The Netherlands
- Leon F.A.G. Massuger
- Radboud University Medical Centre, Department of Obstetrics and Gynecology, Nijmegen 6525 GA, The Netherlands
- Anne M. van Altena
- Radboud University Medical Centre, Department of Obstetrics and Gynecology, Nijmegen 6525 GA, The Netherlands
- Tanja Pejovic
- Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA
- Yukie Bean
- Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA
- Melissa Kellar
- Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA
- Linda S. Cook
- Division of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA
- Nhu D. Le
- Cancer Control Research, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada
- Angela Brooks-Wilson
- Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada
- Jacek Gronwald
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland
- Cezary Cybulski
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland
- Anna Jakubowska
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland
- Jan Lubiński
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin 71-252, Poland
- Nicolas Wentzensen
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
- Louise A. Brinton
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
- Jolanta Lissowska
- Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Institute-Oncology Center, Warsaw 02-034, Poland
- Estrid Hogdall
- Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Centre, DK-2100 Copenhagen, Denmark
- Svend Aage Engelholm
- Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Copenhagen DK-2100, Denmark
- Claus Hogdall
- Department of Gynaecology, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark
- Lene Lundvall
- Department of Gynaecology, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark
- Lotte Nedergaard
- Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen DK-2100, Denmark
- Paul D.P. Pharoah
- The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
- Ed Dicks
- The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK
- Honglin Song
- The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK
- Jonathan P. Tyrer
- The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK
- Iain McNeish
- Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
- Nadeem Siddiqui
- Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow G4 0SF, UK
- Karen Carty
- Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK
- Rosalind Glasspool
- Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK
- James Paul
- Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow G12 0YN, UK
- Ian G. Campbell
- Department of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia
- Diana Eccles
- Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK
- Alice S. Whittemore
- Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
- Valerie McGuire
- Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
- Joseph H. Rothstein
- Department of Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
- Weiva Sieh
- Department of Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
- Steven A. Narod
- Women’s College Research Institute, University of Toronto, Toronto, ON M5S 1A8, Canada
- Catherine M. Phelan
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
- John R. McLaughlin
- Public Health Ontario, Samuel Lunenfeld Research Institute, Toronto, ON M5T 3L9, Canada
- Harvey A. Risch
- Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT 06510, USA
- Hoda Anton-Culver
- Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, CA 92617, USA
- Argyrios Ziogas
- Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, CA 92617, USA
- Usha Menon
- MRC Clinical Trials at UCL, Institute of Clinical Trials & Methodology, Population Health Sciences, University College London, London, WC1V 6LJ, UK
- Simon A. Gayther
- Department of Biomedical Sciences and Center for Cancer Prevention and Translational Genomics, Samuel Oschin Comprensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
- Aleksandra Gentry-Maharaj
- MRC Clinical Trials at UCL, Institute of Clinical Trials & Methodology, Population Health Sciences, University College London, London, WC1V 6LJ, UK
- Susan J. Ramus
- School of Women’s and Children’s Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
- Anna H. Wu
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
- Celeste Leigh Pearce
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
- Alice W. Lee
- Department of Public Health, California State University, Fullerton, CA 92831, USA
- Malcolm C. Pike
- Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY 10065, USA
- Jolanta Kupryjanczyk
- Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw 02-034, Poland
- Agnieszka Podgorska
- Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw 02-034, Poland
- Joanna Plisiecka-Halasa
- Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute-Oncology Center, Warsaw 02-034, Poland
- Wlodzimierz Sawicki
- Department of Obstetrics, Gynecology and Oncology, Second Faculty of Medicine, Medical University of Warsaw, Mazovian Bródno Hospital, Warsaw 03-242, Poland
- Ellen L. Goode
- Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
- Andrew Berchuck
- Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
- Ovarian Cancer Association Consortium
- DOI
- https://doi.org/10.3390/ijms19092473
- Journal volume & issue
-
Vol. 19,
no. 9
p. 2473
Abstract
Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported association between rs495139 in the TYMS-ENOSF1 3′ gene region and increased risk of mucinous ovarian carcinoma (MOC) in an independent sample. Genotypes from 24,351 controls to 15,000 women with invasive OC, including 665 MOC, were available. We estimated per-allele odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression, and meta-analysis when combining these data with our previous report. The association between rs495139 and MOC was not significant in the independent sample (OR = 1.09; 95% CI = 0.97–1.22; p = 0.15; N = 665 cases). Meta-analysis suggested a weak association (OR = 1.13; 95% CI = 1.03–1.24; p = 0.01; N = 1019 cases). No significant association with risk of other OC histologic types was observed (p = 0.05 for tumor heterogeneity). In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa (r = 0.51, p = 1.7 × 10−28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small.
Keywords
- consortia
- enolase superfamily member 1
- expression quantitative trait locus
- genetics
- gynecology
- ovarian neoplasms
- single-nucleotide polymorphism
- thymidylate synthase
