IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease

Milena J. Tosiek; Laurence Fiette; Sary El Daker; Gérard Eberl; Antonio A. Freitas

doi:10.1038/ncomms10888

Nature Communications (Mar 2016)

IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease

Milena J. Tosiek,
Laurence Fiette,
Sary El Daker,
Gérard Eberl,
Antonio A. Freitas

Affiliations

Milena J. Tosiek: Department of Immunology, Unité de Biologie des Populations Lymphocytaires, Institut Pasteur
Laurence Fiette: Department of Infection and Epidemiology, Unité d’Histopathologie Humaine et Modèles Animaux, Institut Pasteur
Sary El Daker: Department of Immunology, Unité de Biologie des Populations Lymphocytaires, Institut Pasteur
Gérard Eberl: CNRS, URA1961
Antonio A. Freitas: Department of Immunology, Unité de Biologie des Populations Lymphocytaires, Institut Pasteur

DOI: https://doi.org/10.1038/ncomms10888
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Transcription factors directing T cell fate are induced by instructive signals such as cytokines. Here the authors show that IL-15 promotes Foxp3 and inhibits RORγt expression in CD4 T cells, and that IL-15 is critical to suppress colitis by maintaining the Treg to Th1/Th17 ratio in a mouse model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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