Nature Communications (Jul 2020)
An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
- Jamie Zagozewski,
- Ghazaleh M. Shahriary,
- Ludivine Coudière Morrison,
- Olivier Saulnier,
- Margaret Stromecki,
- Agnes Fresnoza,
- Gareth Palidwor,
- Christopher J. Porter,
- Antoine Forget,
- Olivier Ayrault,
- Cynthia Hawkins,
- Jennifer A. Chan,
- Maria C. Vladoiu,
- Lakshmikirupa Sundaresan,
- Janilyn Arsenio,
- Michael D. Taylor,
- Vijay Ramaswamy,
- Tamra E. Werbowetski-Ogilvie
Affiliations
- Jamie Zagozewski
- Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba
- Ghazaleh M. Shahriary
- Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba
- Ludivine Coudière Morrison
- Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba
- Olivier Saulnier
- The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children
- Margaret Stromecki
- Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba
- Agnes Fresnoza
- Central Animal Care Services, University of Manitoba
- Gareth Palidwor
- Ottawa Bioinformatics Core Facility, Ottawa Hospital Research Institute
- Christopher J. Porter
- Ottawa Bioinformatics Core Facility, Ottawa Hospital Research Institute
- Antoine Forget
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Olivier Ayrault
- Institut Curie, PSL Research University, CNRS UMR, INSERM
- Cynthia Hawkins
- The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children
- Jennifer A. Chan
- Department of Pathology & Laboratory Medicine, University of Calgary
- Maria C. Vladoiu
- The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children
- Lakshmikirupa Sundaresan
- The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children
- Janilyn Arsenio
- Departments of Internal Medicine and Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba
- Michael D. Taylor
- The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children
- Vijay Ramaswamy
- The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children
- Tamra E. Werbowetski-Ogilvie
- Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba
- DOI
- https://doi.org/10.1038/s41467-020-17357-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.
