Beilstein Journal of Organic Chemistry (Dec 2013)

Flow microreactor synthesis in organo-fluorine chemistry

  • Hideki Amii,
  • Aiichiro Nagaki,
  • Jun-ichi Yoshida

DOI
https://doi.org/10.3762/bjoc.9.314
Journal volume & issue
Vol. 9, no. 1
pp. 2793 – 2802

Abstract

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Organo-fluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Despite increased demand in wide fields of science, synthesis of fluoro-organic compounds is still often faced with problems such as the difficulties in handling of fluorinating reagents and in controlling of chemical reactions. Recently, flow microreactor synthesis has emerged as a new methodology for producing chemical substances with high efficiency. This review outlines the successful examples of synthesis and reactions of fluorine-containing molecules by the use of flow microreactor systems to overcome long-standing problems in fluorine chemistry.

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