Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

Abstract

Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has anti-Salmonella functions that occur in advance of cell death induction.