Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

Samantha J. Batista; Katherine M. Still; David Johanson; Jeremy A. Thompson; Carleigh A. OʼBrien; John R. Lukens; Tajie H. Harris

doi:10.1038/s41467-020-17491-z

Nature Communications (Jul 2020)

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

Samantha J. Batista,
Katherine M. Still,
David Johanson,
Jeremy A. Thompson,
Carleigh A. OʼBrien,
John R. Lukens,
Tajie H. Harris

Affiliations

Samantha J. Batista: Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia
Katherine M. Still: Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia
David Johanson: Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia
Jeremy A. Thompson: Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia
Carleigh A. OʼBrien: Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia
John R. Lukens: Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia
Tajie H. Harris: Center for Brain Immunology and Glia, Department of Neuroscience, University of Virginia

DOI: https://doi.org/10.1038/s41467-020-17491-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Control over T. gondii infection in the brain involves microglial cells, but how these cells execute this control is not clear. Here the authors show that unlike IL-1β dominant macrophages, microglia are primed for gasdermin-D-dependent IL-1α production that is critical for protection against T. gondii infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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