Journal of the Serbian Chemical Society (Jan 2008)

Antimicrobial activity of some isatin-3-thiosemicarbazone complexes

  • Konstantinović Sandra S.,
  • Radovanović Blaga C.,
  • Sovilj Sofija P.,
  • Stanojević Svetlana

DOI
https://doi.org/10.2298/JSC0801007K
Journal volume & issue
Vol. 73, no. 1
pp. 7 – 13

Abstract

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Isatin-3-thiosemicarbazone complexes with Co(II), Ni(II), Cu(II), Zn(II), Hg(II) and Pd(II) were synthesized and evaluated for their antimicrobial activity against 7 pathogenic bacteria and 4 fungi. The complexes have an en­hanced activity compared to the ligand due to transition metal involved in coor­dination. The anti-amoebic activity in vitro was evaluated against the HM1:IMSS strain of Entamoeba histolytica and the results were compared with the standard drug, metronidazole. The preliminary test results showed that the complexes had better anti-amoebic activity than their respective ligands. Moreover, the com­plexes showed better inhibition of the test organism.

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