Synthesis of Novel Michael Adducts and Study of their Antioxidant and Antimicrobial Activities

Abstract

In the current study, the Michael addition reaction of nitromethane to chalcones were studied. 4-benzeloxy benzaldehyde was synthesized from 4-hydroxybenzaldehde and benzyl bromide, which was then converted to chalcone derivatives by reaction with substituted acetophenones, and finally nitromethane was added to give Michael adducts. The structures of the synthesized compounds were characterized by FTIT, 1H NMR, and 13C NMR spectroscopy. All the products were screened for antibacterial activities against Staphylococcus aureus G (+ve) and Escherichia coli G (-ve) microorganisms and antifungal activity against candida albicans besides their antioxidant activity.

Keywords

• michael addition reaction
• nitroalkane
• chalcones
• antioxidant
• antimicrobial activities