Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells

Stefan Semrau; Johanna E. Goldmann; Magali Soumillon; Tarjei S. Mikkelsen; Rudolf Jaenisch; Alexander van Oudenaarden

doi:10.1038/s41467-017-01076-4

Nature Communications (Oct 2017)

Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells

Stefan Semrau,
Johanna E. Goldmann,
Magali Soumillon,
Tarjei S. Mikkelsen,
Rudolf Jaenisch,
Alexander van Oudenaarden

Affiliations

Stefan Semrau: Hubrecht Institute–KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht
Johanna E. Goldmann: Whitehead Institute for Biomedical Research
Magali Soumillon: Broad Institute
Tarjei S. Mikkelsen: Broad Institute
Rudolf Jaenisch: Whitehead Institute for Biomedical Research
Alexander van Oudenaarden: Hubrecht Institute–KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht

DOI: https://doi.org/10.1038/s41467-017-01076-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

Read online

Commitment to different fates by differentiating pluripotent cells depends upon integration of external and internal signals. Here the authors analyse the entry of mouse embryonic stem cells into retinoic acid-mediated differentiation using single cell transcriptomics with high temporal resolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal