Stochastic Global Model for the Prediction of the Asymptotic CSDs Using Antisolvent Crystallization Processes

Abstract

A stochastic global formulation for the description of antisolvent mediated crystal growth processes is discussed based on the Fokker-Planck equation (FPE). The obtained global model is used to define an operating map of the crystallization process, where asymptotic iso-mean and iso-variance curves are reported in an antisolvent flowrate – temperature plane. Using the obtained asymptotic operational map, three different CSDs have been predicted and compared, both in asymptotic and then dynamic conditions, using experimental results.