Delayed Inflammatory Reactions After Hyaluronic Acid Filling of Neck Lines: A Case Report

Abstract

Zhiyu Li,1 Pu Zhao,2 Qing Xu,3 Jianhai Bi,1,4,5,* Ran Huo1,4,5,* 1Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People’s Republic of China; 2Department of Plastic Surgery, Liaocheng Hospital of Traditional Chinese Medicine, Liaocheng, People’s Republic of China; 3Department of Plastic and Aesthetic Surgery, Maternity and Child Health Care of Zaozhuang, Zaozhuang, People’s Republic of China; 4Department of Plastic and Aesthetic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China; 5Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianhai Bi; Ran Huo, Email [email protected]; [email protected]: The incidence of adverse events after hyaluronic acid filling is gradually increasing. In addition to acute reactions in the early postoperative period, there have been some cases of delayed inflammatory reactions. However, such events are rarely reported in Asia, which may be due to atypical symptoms, long intervals, and misidentification of the product quality. Herein, we present a case in which erythema of the neck appeared three weeks after hyaluronic acid injection into the neck lines and a delayed inflammatory reaction was diagnosed. Watchful waiting was performed, and the erythema subsided spontaneously after two weeks. This case suggests that in patients with a history of hyaluronic acid injections who develop allergic and inflammatory reactions after an interval, it is important to consider whether the reaction is a delayed inflammatory reaction, and if aggressive intervention is necessary.Keywords: delayed inflammatory reactions, hyaluronic acid, neck lines, root canal, COVID-19 vaccination

Keywords

• delayed inflammatory reactions
• hyaluronic acid
• neck lines
• root canal
• covid-19 vaccination.