Clinical Nutrition Open Science (Oct 2025)

Lower RXRA and TFRC expression despite higher mineral and vitamin intake in diabetic pregnant women with pregnancy-specific urinary incontinence

  • Sarah Maria Barneze Costa,
  • Raghavendra Lakshmana Shetty Hallur,
  • Matheus Naia Fioretto,
  • João Paulo de Castro Marcondes,
  • Igor de Carvalho Deprá,
  • Camila Renata Corrêa,
  • Danielle Cristina Honorio França,
  • David Rafael Abreu Reyes,
  • Sérgio Luis Felisbino,
  • Angélica Mércia Pascon Barbosa,
  • Marilza Cunha Vieira Rudge,
  • M.V.C. Rudge,
  • A.M.P. Barbosa,
  • I.M.P. Calderon,
  • F.P. Souza,
  • T. Lehana,
  • C.F.O. Graeff,
  • C.G. Magalhães,
  • R.A.A. Costa,
  • S.A.M. Lima,
  • M.R.K. Rodrigues,
  • S.L. Felisbino,
  • W.F. Barbosa,
  • F.J. Campos,
  • G. Bossolan,
  • J.E. Corrente,
  • H.R.C. Nunes,
  • J.F. Abbade,
  • P.S. Rossignoli,
  • C.R. Pedroni,
  • Á.N. Atallah,
  • Z.I. Jármy-Di Bella,
  • S.M.M. Uchôa,
  • M.A.H. Duarte,
  • E.A. Mareco,
  • M.E. Sakalem,
  • N.M. Martinho,
  • D.G. Bussaneli,
  • M.I.G. Orlandi,
  • C. Pascon,
  • T.D. Dangió,
  • C.V.C. Rudge,
  • F. Piculo,
  • G.M. Prata,
  • R.E. Avramidis,
  • C.N.F. Carvalho,
  • A.B.M. Magyori,
  • G.T.A. Nava,
  • T.C.D. Caldeirão,
  • R.H.L. Shetty,
  • D.R.A. Reyes,
  • F.C.B. Alves,
  • J.P.C. Marcondes,
  • M.L.S. Takemoto,
  • C.B. Prudencio,
  • F.A. Pinheiro,
  • C.I. Sartorao Filho,
  • S.B.C.V. Quiroz,
  • T. Pascon,
  • S.K. Nunes,
  • B.B. Catinelli,
  • F.V.D.S. Reis,
  • R.G. Oliveira,
  • S.M.B. Costa,
  • M.O. Menezes,
  • N.J. Santos,
  • E.M.A. Enriquez,
  • L. Takano,
  • A.M. Carr,
  • G.A. Garcia,
  • L.F. Iamundo,
  • H.C.M. Bassin,
  • V.P. Barbosa,
  • M. Jacomin,
  • A.J.B. Silva,
  • I.O. Lourenço,
  • J. Marostica de Sá,
  • I.P. Caruso,
  • L.T. Rasmussen,
  • V.K.C. Nogueira,
  • J.T. Ribeiro-Paes,
  • D.C.H. França,
  • H.V.M. Bastos,
  • M.L.A. Heliodoro,
  • M.N. Kuroda,
  • H.L. Carvalho

DOI
https://doi.org/10.1016/j.nutos.2025.07.010
Journal volume & issue
Vol. 63
pp. 113 – 130

Abstract

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Summary: Background: Gestational diabetes mellitus (GDM) and pregnancy-specific urinary incontinence (PSUI) pose significant health challenges for pregnant women, but their metabolic and molecular underpinnings remain poorly understood. Methods: In this cross-sectional study, 1,105 participants from the DIAMATER cohort were categorized based on GDM and PSUI status. Dietary intake of iron, magnesium, zinc, and vitamins A and D was assessed through dietary recalls, while serum levels, gene expression (MTF1, RXRA, TFRC, TRPM6), and protein expression were analyzed using standard techniques. Oxidative stress markers were also measured. Results: GDM-PSUI participants exhibited lower RXRA and TFRC gene expression and decreased TFRC protein levels despite higher intake of magnesium, zinc, and vitamin D compared to GDM controls without PSUI. Serum mineral levels and oxidative stress markers did not differ significantly between groups. Conclusions: Lower RXRA and TFRC expression in GDM-PSUI women, despite increased mineral and vitamin intake, suggests potential molecular targets for interventions aimed at improving management strategies in this population.

Keywords