Clinical and Applied Thrombosis/Hemostasis (Apr 2024)

Reference Value Fibrin Monomer in Healthy Children: A Cross-Sectional Study

  • Ta Anh Tuan MD, PhD,
  • Tran Dang Xoay MD,
  • Tran Thi Kieu My MD, PhD,
  • Nguyen Thi Duyen MD,
  • Nguyen Thi Trang BMed,
  • Nguyen Tat Kien MD,
  • Chu Thanh Son MD, PhD,
  • Nguyen Van Thang MD,
  • Thieu Quang Quan MD,
  • Dau Viet Hung MD, PhD

DOI
https://doi.org/10.1177/10760296241247560
Journal volume & issue
Vol. 30

Abstract

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The objective of this study is to determine the fibrin monomer reference intervals in healthy children. This cross-sectional study was conducted in the Hematology Department at Vietnam National Children's Hospital (April 2023 to March 2024). Children without prior history of clotting disorders or anticoagulants use hospitalized in preparation for orthopedic surgery or inguinal hernia surgery were enrolled in the study. The fibrin monomer test method was the quantitative fibrin monomer test on the STA-R system (Diagnostica Stago™, France). Eighty-six children (58 males and 28 females) were enrolled in the study. The median (interquartile range, 2.5th-97.5th) fibrin monomer value of the study subjects was 2.56 (0.11-5.93) µg/mL, with no statistically significant difference in fibrin monomer values among the age groups of 1 month to 3 years, 3 years to 13 years, and 13 years to 18 years. This is the first study conducted in Vietnam to determine reference values of fibrin monomer in children. This information can help in the diagnosis and treatment of early hypercoagulation stage and disseminated intravascular coagulation in children.