Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats

Abstract

Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female offspring. When ET was accompanied with in vitro culture in R1ECM, not only the female offspring, but also males demonstrated alleviation of hypertension. Conclusions: IVC at the preimplantation embryo stage affected the manifestation of hypertension in the adult ISIAH offspring.

Keywords

• in vitro culture
• embryo transfer
• offspring neurodevelopment
• blood pressure
• hypertensive rats