UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

Sophia Maschalidi; Paula Nunes-Hasler; Clarissa R Nascimento; Ignacio Sallent; Valérie Lannoy; Meriem Garfa-Traore; Nicolas Cagnard; Fernando E. Sepulveda; Pablo Vargas; Ana-Maria Lennon-Duménil; Peter van Endert; Thierry Capiod; Nicolas Demaurex; Guillaume Darrasse-Jèze; Bénédicte Manoury

doi:10.1038/s41467-017-01601-5

Nature Communications (Nov 2017)

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

Sophia Maschalidi,
Paula Nunes-Hasler,
Clarissa R Nascimento,
Ignacio Sallent,
Valérie Lannoy,
Meriem Garfa-Traore,
Nicolas Cagnard,
Fernando E. Sepulveda,
Pablo Vargas,
Ana-Maria Lennon-Duménil,
Peter van Endert,
Thierry Capiod,
Nicolas Demaurex,
Guillaume Darrasse-Jèze,
Bénédicte Manoury

Affiliations

Sophia Maschalidi: INSERM UMR1163, Laboratory of Normal and Pathological Homeostasis of the Immune System, Imagine Institute
Paula Nunes-Hasler: Department of Cell Physiology and Metabolism, University of Geneva
Clarissa R Nascimento: Faculté de médecine Paris Descartes, Université Paris Descartes
Ignacio Sallent: Faculté de médecine Paris Descartes, Université Paris Descartes
Valérie Lannoy: Faculté de médecine Paris Descartes, Université Paris Descartes
Meriem Garfa-Traore: Faculté de médecine Paris Descartes, Université Paris Descartes
Nicolas Cagnard: Faculté de médecine Paris Descartes, Université Paris Descartes
Fernando E. Sepulveda: INSERM UMR1163, Laboratory of Normal and Pathological Homeostasis of the Immune System, Imagine Institute
Pablo Vargas: Institut Curie, PSL Research University, Centre National de la Recherche Scientifique, UMR 144
Ana-Maria Lennon-Duménil: Institut National de la Santé et de la Recherché Médicale, Unité 932, Institut Curie, PSL Research University
Peter van Endert: Faculté de médecine Paris Descartes, Université Paris Descartes
Thierry Capiod: Faculté de médecine Paris Descartes, Université Paris Descartes
Nicolas Demaurex: Department of Cell Physiology and Metabolism, University of Geneva
Guillaume Darrasse-Jèze: Faculté de médecine Paris Descartes, Université Paris Descartes
Bénédicte Manoury: Faculté de médecine Paris Descartes, Université Paris Descartes

DOI: https://doi.org/10.1038/s41467-017-01601-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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