OncoTargets and Therapy (2021-03-01)

Biological Function of HYOU1 in Tumors and Other Diseases

  • Rao S,
  • Oyang L,
  • Liang J,
  • Yi P,
  • Han Y,
  • Luo X,
  • Xia L,
  • Lin J,
  • Tan S,
  • Hu J,
  • Wang H,
  • Tang L,
  • Pan Q,
  • Tang Y,
  • Zhou Y,
  • Liao Q

Journal volume & issue
Vol. Volume 14
pp. 1727 – 1735

Abstract

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Shan Rao,1 Linda Oyang,1 Jiaxin Liang,1 Pin Yi,1 Yaqian Han,1 Xia Luo,1 Longzheng Xia,1 Jinguan Lin,1 Shiming Tan,1 Jiaqi Hu,1 Hui Wang,1 Lu Tang,1,2 Qing Pan,1,2 Yanyan Tang,1 Yujuan Zhou,1 Qianjin Liao1 1Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, People’s Republic of China; 2University of South China, Hengyang, 421001, Hunan, People’s Republic of ChinaCorrespondence: Qianjin Liao; Yujuan ZhouHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Changsha, 410013, Hunan, People’s Republic of ChinaTel +86-731-88651681Fax +86-731-88651999Email [email protected]; [email protected]: Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.Keywords: HYOU1, tumor, endoplasmic reticulum, anti-tumor immunity

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