Flavonifractor (Eubacterium) plautii bloodstream infection following acute cholecystitis
Fabian K. Berger,
Nadine Schwab,
Matthias Glanemann,
Rainer M. Bohle,
Barbara Gärtner,
Heinrich V. Groesdonk
Affiliations
Fabian K. Berger
Institute of Medical Microbiology and Hygiene, Saarland University Medical Center, Homburg, Saar, Germany; Corresponding author at: Kirrberger Street, Building 43, 66424, Homburg, Saar, Germany.
Nadine Schwab
Department of Anesthesiology, Intensive Care Medicine and Pain Medicine, Saarland University Medical Center, University of Saarland, Homburg, Saar, Germany
Matthias Glanemann
Department for General, Visceral, Vascular, and Pediatric Surgery, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg, Saar, Germany
Rainer M. Bohle
Institute of Pathology, Saarland University Medical Center, Saarland University, Homburg, Saar, Germany
Barbara Gärtner
Institute of Medical Microbiology and Hygiene, Saarland University Medical Center, Homburg, Saar, Germany
Heinrich V. Groesdonk
Department of Anesthesiology, Intensive Care Medicine and Pain Medicine, Saarland University Medical Center, University of Saarland, Homburg, Saar, Germany
Flavonifractor plautii (formerly Eubacterium plautii) is an anaerobic gram positive rod shaped bacterium belonging to the family of Clostridiales, and a common member of the human gut microbiome. However, it is very rarely isolated from clinical human specimens, so data about its clinical significance are scarce. Here we report of a bloodstream infection due to F. plautii following gangrenous cholecystitis in a 69 year old man. After cholecystectomy and empirical antimicrobial treatment with ceftriaxone and metronidazole the patient recovered.F. plautii was the only bacterium detected in blood culture, suggesting that it might have been causative for cholecystitis. Antimicrobial resistance testing identified decreased susceptibilities against linezolid and penicillin indicating that a targeted therapy might be necessary. F. plautii can be considered a potential pathogen for cholecystitis. Keywords: Sepsis, Anaerobe, Gall bladder, Antibiotic resistance, Susceptibility
