Nature Communications (May 2021)
LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
Abstract
How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.