Nature Communications (May 2021)

LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

  • María Ángeles Marqués-Torrejón,
  • Charles A. C. Williams,
  • Benjamin Southgate,
  • Neza Alfazema,
  • Melanie P. Clements,
  • Claudia Garcia-Diaz,
  • Carla Blin,
  • Nerea Arranz-Emparan,
  • Jane Fraser,
  • Noor Gammoh,
  • Simona Parrinello,
  • Steven M. Pollard

DOI
https://doi.org/10.1038/s41467-021-22813-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.