Clinical significance of immune-related antigen CD58 in gliomas and analysis of its potential core related gene clusters
Zhi Tian,
Wei Jia,
Zhao Wang,
Hui Mao,
Jingjing Zhang,
Qiongya Shi,
Xing Li,
Shaoyu Song,
Jiao Zhang,
Yingjie Zhu,
Bo Yang,
Chunhai Huang,
Jun Huang
Affiliations
Zhi Tian
Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China
Wei Jia
Medical College of Jishou University, Jishou, Hunan, 416000 PR China
Zhao Wang
Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China
Hui Mao
Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China
Jingjing Zhang
Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China
Qiongya Shi
Medical College of Jishou University, Jishou, Hunan, 416000 PR China
Xing Li
Medical College of Jishou University, Jishou, Hunan, 416000 PR China
Shaoyu Song
Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China
Jiao Zhang
Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China
Yingjie Zhu
Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China
Bo Yang
Department of Pathology, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China
Chunhai Huang
Department of Neurosurgery, First Affiliated Hospital, Jishou University, Jishou, Hunan, 416000 PR China; Corresponding author. Department of Neurosurgery, First Affiliated Hospital, Jishou University, the intersection of Jianxin Road and Qianzhou Shiji Avenue, Jishou City, Hunan Province, 416000, PR China.
Jun Huang
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008 PR China; Corresponding author. Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha City, Hunan Province, 410008, PR China.
Background: The clinical significance of immune-related antigen CD58 in gliomas remains uncertain. The aim of this study was to examine the clinical importance and possible core related genes of CD58 in gliomas. Methods: Pan-cancer analysis was to observe the association between CD58 and different tumors, glioma RNA sequencing data and clinical sample analyses were used to observe the relationship between CD58 and glioma, shRNA interference models were to observe the impact of CD58 on glioma cell function, and four glioma datasets and two online analysis platforms were used to explore the core related genes affecting the correlation between CD58 and glioma. Results: High CD58 expression was associated with worse prognosis in various tumors and higher malignancy in glioma. Down regulation of CD58 expression was linked to decreased proliferation, increased apoptosis, and reduced metastasis in glioma cells. The pathways involved in CD58-related effects were enriched for immune cell adhesion and immune factor activation, and the core genes were CASP1, CCL2, IL18, MYD88, PTPRC, and TLR2. The signature of CD58 and its core-related genes showed superior predictive power for glioma prognosis. Conclusion: High CD58 expression is correlated with more malignant glioma types, and also an independent risk factor for mortality in glioma. CD58 and its core-related genes may serve as novel biomarkers for diagnosing and treating glioma.
