DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity

Abstract

Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver failure). We describe a case of DILI in a 9-month-old infant caused by chronic therapy with phenobarbital.

Keywords

• dili
• infant
• phenobarbital
• cyp3a4