Clinical Interventions in Aging (Jun 2020)

Comparative Study of Two Short-Form Versions of the Montreal Cognitive Assessment for Screening of Post-Stroke Cognitive Impairment in a Chinese Population

  • Wei J,
  • Jin X,
  • Chen B,
  • Liu X,
  • Zheng H,
  • Guo R,
  • Liang X,
  • Fu C,
  • Zhang Y

Journal volume & issue
Vol. Volume 15
pp. 907 – 914

Abstract

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Jingjing Wei,1– 3,* Xianglan Jin,2,* Baoxin Chen,2 Xuemei Liu,4 Hong Zheng,4 Rongjuan Guo,2 Xiao Liang,3 Chen Fu,2,4 Yunling Zhang2,3 1Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 4Central Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunling ZhangDepartment of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 1 Xiyuan Playground, Haidian District, Beijing 100091, People’s Republic of ChinaTel/Fax +86-10-6283-5960Email [email protected] FuCentral Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, 6 First Block, Fangxingyuan, Fengtai District, Beijing 100078, People’s Republic of ChinaTel +86-10-6768-9634Fax +86-10-67691949Email [email protected]: Cognitive impairment (CI) is one of the most significant post-stroke complications. The Montreal Cognitive Assessment (MoCA) is widely applied to the early screening of post-stroke CI (PSCI), and has good sensitivity and specificity, but needs a long time to administer. Clinicians and researchers need shorter, more effective cognitive testing tools. The purpose of this study was to detect the sensitivity and specificity of two different short-form versions of the MoCA (SF-MoCA) for screening of PSCI in a Chinese population.Methods: A total of 2,989 stroke participants were included from 14 hospitals in northern and southern China between June 2011 and September 2013. The sensitivity and specificity of the two SF-MoCA versions were compared.Results: Using an MoCA score < 26 as the critical value, the National Institute of Neurological Disease and Stroke–Canadian Stroke Network SF-MoCA showed sensitivity of 91% and specificity of 63% (PPV 71%, BPV 87%) with scores ≤ 10 points. The sensitivity and specificity of the Bocti SF-MoCA were 92% and 69% (PPV 75%, BPV 89%) with scores ≤ 7, respectively. The area under the curve was 0.885 (95% CI 0.873– 0.897) and 0.912 (95% CI 0.902– 0.922), respectively.Conclusion: The Bocti SF-MoCA can be used as a briefer and more effective screening tool for PSCI in Chinese.Keywords: cognitive dysfunction, Montreal Cognitive Assessment, MoCA, stroke, sensitivity, specificity

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