Communications Biology (Sep 2021)

Membrane anchoring facilitates colocalization of enzymes in plant cytochrome P450 redox systems

  • Tomas Laursen,
  • Hiu Yue Monatrice Lam,
  • Kasper Kildegaard Sørensen,
  • Pengfei Tian,
  • Cecilie Cetti Hansen,
  • Jay T. Groves,
  • Knud Jørgen Jensen,
  • Sune M. Christensen

DOI
https://doi.org/10.1038/s42003-021-02604-1
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 9

Abstract

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Laursen et al. investigates the role of membrane anchoring for the organization and efficiency of P450-driven plant metabolism. They report an original experimental design to monitor interactions between anchoring segments of membrane-bound enzymes at the single molecule level, using the cytochrome P450 oxidoreductase (POR) transmembrane segment as a model, and propose that membrane anchoring has played a key role in the evolution of P450- based metabolic pathways in plants.