Membrane anchoring facilitates colocalization of enzymes in plant cytochrome P450 redox systems

Tomas Laursen; Hiu Yue Monatrice Lam; Kasper Kildegaard Sørensen; Pengfei Tian; Cecilie Cetti Hansen; Jay T. Groves; Knud Jørgen Jensen; Sune M. Christensen

doi:10.1038/s42003-021-02604-1

Communications Biology (Sep 2021)

Membrane anchoring facilitates colocalization of enzymes in plant cytochrome P450 redox systems

Tomas Laursen,
Hiu Yue Monatrice Lam,
Kasper Kildegaard Sørensen,
Pengfei Tian,
Cecilie Cetti Hansen,
Jay T. Groves,
Knud Jørgen Jensen,
Sune M. Christensen

Affiliations

Tomas Laursen: Department of Plant and Environmental Sciences, University of Copenhagen
Hiu Yue Monatrice Lam: Department of Chemistry, University of California
Kasper Kildegaard Sørensen: Department of Chemistry, University of Copenhagen
Pengfei Tian
Cecilie Cetti Hansen: Department of Plant and Environmental Sciences, University of Copenhagen
Jay T. Groves: Department of Chemistry, University of California
Knud Jørgen Jensen: Department of Chemistry, University of Copenhagen
Sune M. Christensen: Department of Chemistry, University of California

DOI: https://doi.org/10.1038/s42003-021-02604-1
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 9

Abstract

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Laursen et al. investigates the role of membrane anchoring for the organization and efficiency of P450-driven plant metabolism. They report an original experimental design to monitor interactions between anchoring segments of membrane-bound enzymes at the single molecule level, using the cytochrome P450 oxidoreductase (POR) transmembrane segment as a model, and propose that membrane anchoring has played a key role in the evolution of P450- based metabolic pathways in plants.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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